Wymagania sprzętowe dla Windows:

OS: Windows Vista Service Pack 2 32-bit
Processor: Intel Core 2 DUO 2.4 GHz / AMD Athlon X2 2.7 GHz
Memory: 2 GB RAM
Graphics: DirectX10 Compatible ATI Radeon HD 3870 / NVIDIA 8800 GT / Intel HD 3000 Integrated Graphics
Storage: 30 GB available space
Sound Card: DirectX Compatible

Wymagania sprzętowe dla Mac:

OS: OS X 10.8.5 (Mountain Lion), 10.9 (Mavericks)
Processor: 2.2 GHz Intel Core 2 Duo (Dual-Core)
Memory: 4 GB RAM
Graphics: ATI Radeon HD 3870 / NVidia Geforce 640M
Storage: 30 GB available space
Additional Notes: BioShock Infinite supports both the Microsoft Xbox 360 wired gamepad and the PlayStation 3 Dualshock 3 Wireless Controller in addition to the Macintosh mouse and keyboard.
Supported Video Cards:NVIDIA GeForce® 640M, 650M, 660M, 675MX, 680MX, 750M, 755M, 775M, 780M ATI Radeon HD 3870, HD 4850, HD 5670, HD 5750, HD 5770, HD 5870, HD 6750, HD 6770, HD 6970, HD 7950 (10.9.2 only) FirePro D300, D500, D700 Intel HD Graphics 4000, 5000, Iris, Iris Pro
NOTICE: This game is not supported on volumes formatted as Mac OS Extended (Case Sensitive)
NOTICE: The following video chipsets are unsupported for BioShock Infinite: ATI RADEON 2000 series, HD 4670, HD 6490M and 6630M, NVIDIA 9000 series, 320M, 330M, Intel HD 3000, Intel Integrated GMA chipsets and 3100

Wymagania sprzętowe dla Linux:

OS: Ubuntu 14.10, Mint 17.1 or similar Linux distribution
Processor: Intel Core 2 DUO 2.4 GHz / AMD Athlon X2 2.7 GHz
Memory: 4 GB RAM
Graphics: NVidia/AMD OpenGL 4.1/DirectX 10.0 level compatible
Storage: 20 GB available space
Sound Card: ALSA/PulseAudio compatible