Wymagania sprzętowe dla Windows:

OS: Windows XP SP3
Processor: 2.4 GHz Dual Core Processor
Memory: 2 GB(XP)/ 2 GB(Vista)
Hard Disk Space: 13 GB free
Video Memory: 256 MB
Video Card: NVIDIA GeForce 8500 /ATI Radeon HD 2600
Sound: DirectX 9.0c Compatible
Other Requirements:Initial installation requires one-time internet connection for Steam authentication; software installations required (included with the game) include Steam Client, DirectX 9, Microsoft .NET 4 Framework, Visual C++ Redistributable 2005, Visual C++ Redistributable 2008, Visual C++ Redistributable 2010, and AMD CPU Drivers (XP Only/AMD Only)

Wymagania sprzętowe dla Mac:

OS: 10.7.5 (Lion), 10.8.4 (Mountain Lion)
Processor: 2.4 GHz Intel Core 2 Duo (Dual-Core)
Memory: 4 GB RAM
Hard Disk Space: 13 GB
Video Memory: 256 MB
Video Card: ATI Radeon HD 2600 / NVidia Geforce 8800
Additional: Macintosh mouse and keyboard, Borderlands 2 supports both the Xbox 360 wired gamepad AND the PlayStation 3 Dualshock 3 Wireless Controller.
Supported Video Cards:NVIDIA GeForce® 8800, GT 120, 320M, 330M, 640M, 650M, 660M, 675MX, 680MX ATI Radeon HD 2600, HD 3870, HD 4670, HD 4850, HD 5670, HD 5750, HD 5770, HD 5870, HD 6630, HD 6490, HD 6750, HD 6770, HD 6970 Intel HD Graphics 3000, 4000
NOTICE: This game is not supported on volumes formatted as Mac OS Extended (Case Sensitive)
NOTICE: The following video chipsets are unsupported for Borderlands 2: ATI RADEON HD 2400, NVIDIA 8600m, NVIDIA 9400m, 9600m, Intel Integrated GMA 950, Intel Integrated x3100