Wymagania sprzętowe dla Windows:

OS: Windows Vista Service Pack 2 32-bit
Processor: Intel Core 2 DUO 2.4 GHz / AMD Athlon X2 2.7 GHz
Memory: 2GB
Hard Disk Space: 20 GB free
Video Card: DirectX10 Compatible ATI Radeon HD 3870 / NVIDIA 8800 GT / Intel HD 3000 Integrated Graphics
Video Card Memory: 512 MB
Download Size: 150 MB
Sound: DirectX Compatible

Wymagania sprzętowe dla Mac:

OS: 10.8.4 (Mountain Lion)
Processor: 2.2 GHz Intel Core 2 Duo (Dual-Core)
Memory: 4 GB RAM
Hard Disk Space: 30 GB
Video Memory: 512 MB
Video Card: ATI Radeon HD 3870 / NVidia Geforce 640M
Additional: Macintosh mouse and keyboard, BioShock Infinite supports both the Xbox 360 wired gamepad and the PlayStation 3 Dualshock 3 Wireless Controller
Supported Video Cards:NVIDIA GeForce® 640M, 650M, 660M, 675MX, 680MXATI Radeon HD 3870, HD 4850, HD 5670, HD 5750, HD 5770, HD 5870, HD 6750, HD 6770, HD 6970Intel HD Graphics 4000
NOTICE: This game is not supported on volumes formatted as Mac OS Extended (Case Sensitive)
NOTICE: The following video chipsets are unsupported for BioShock Infinite: ATI RADEON 2000 series, HD 4670, HD 6490M and 6630M, NVIDIA 9000 series, 320M, 330M, Intel HD 3000, Intel Integrated GMA chipsets and 3100

Wymagania sprzętowe dla Linux:

OS: Ubuntu 14.10, Mint 17.1 or similar Linux distribution
Processor: Intel Core 2 DUO 2.4 GHz / AMD Athlon X2 2.7 GHz
Memory: 4GB
Hard Disk Space: 20 GB Free
Video Card: NVidia/AMD OpenGL 4.1/DirectX 10.0 level compatible
Video RAM: 1GB
Sound: ALSA/PulseAudio compatible